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Phase Separation In Nervous System
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06
(A) Two major active zone scaffold proteins undergo phase separation regulating the spatiotemporal precision of neurotransmitter release. (B) Active zone condensate mediates synaptic vesicle tethering and docking, while synapsin condensate maintains reserve pool vesicles.
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07
Two small GTPase GEF and GAP co-assemble via phase separation and can be positioned to specific locations as a modular condensates for distinct signalling.
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08
An artistic view of condensed PSDs in a hippocampal neuron.
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